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Naoto T Ueno Selected Research

KW-2450

1/2018Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole.
12/2015Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.

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Naoto T Ueno Research Topics

Disease

136Neoplasms (Cancer)
11/2022 - 11/2002
130Breast Neoplasms (Breast Cancer)
11/2022 - 01/2002
54Inflammatory Breast Neoplasms
10/2021 - 02/2008
47Neoplasm Metastasis (Metastasis)
11/2022 - 06/2009
30Triple Negative Breast Neoplasms
01/2022 - 03/2010
18Pathologic Complete Response
01/2022 - 10/2013
12Circulating Neoplastic Cells
01/2020 - 02/2007
9Ovarian Neoplasms (Ovarian Cancer)
01/2020 - 07/2005
8Disease Progression
01/2022 - 06/2004
6Carcinoma (Carcinomatosis)
09/2020 - 01/2007
5Carcinogenesis
10/2021 - 03/2010
3Graft vs Host Disease (Graft-Versus-Host Disease)
06/2008 - 11/2003
3Renal Cell Carcinoma (Grawitz Tumor)
08/2007 - 11/2003
2Melanoma (Melanoma, Malignant)
02/2018 - 01/2017
2Weight Loss (Weight Reduction)
11/2017 - 02/2012

Drug/Important Bio-Agent (IBA)

26Hormones (Hormone)IBA
01/2022 - 02/2007
19Proteins (Proteins, Gene)FDA Link
01/2022 - 11/2002
19Estrogen ReceptorsIBA
01/2021 - 05/2011
18Biomarkers (Surrogate Marker)IBA
11/2022 - 12/2009
17ErbB Receptors (EGF Receptor)IBA
06/2021 - 06/2007
16human ERBB2 proteinIBA
01/2022 - 06/2010
15Trastuzumab (Herceptin)FDA Link
01/2020 - 06/2004
12Pharmaceutical PreparationsIBA
01/2022 - 01/2009
12Biological ProductsIBA
02/2021 - 02/2007
9Progesterone Receptors (Progesterone Receptor)IBA
05/2021 - 01/2011
9Paclitaxel (Taxol)FDA LinkGeneric
09/2020 - 04/2004
8Epidermal Growth Factor (EGF)IBA
10/2020 - 06/2004
8Erlotinib Hydrochloride (CP 358,774)FDA Link
03/2015 - 06/2007
7Androgen Receptors (Androgen Receptor)IBA
01/2022 - 06/2014
7DNA (Deoxyribonucleic Acid)IBA
01/2020 - 11/2002
7Lapatinib (GW572016)FDA Link
01/2019 - 07/2008
7taxaneIBA
01/2018 - 07/2005
7Messenger RNA (mRNA)IBA
09/2017 - 03/2012
6Cadherins (E-Cadherin)IBA
01/2021 - 05/2010
6MicroRNAs (MicroRNA)IBA
01/2018 - 02/2010
6Phosphotransferases (Kinase)IBA
12/2015 - 07/2005
5Phenobarbital (Luminal)FDA Link
01/2022 - 05/2015
5RNA (Ribonucleic Acid)IBA
10/2021 - 12/2013
5Estrogens (Estrogen)FDA Link
01/2019 - 01/2011
5Histone Deacetylase InhibitorsIBA
01/2019 - 11/2012
5Tyrosine Kinase InhibitorsIBA
07/2014 - 06/2007
4LigandsIBA
11/2022 - 11/2010
4Peptides (Polypeptides)IBA
06/2022 - 04/2014
4Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2022 - 11/2004
4Transcription Factors (Transcription Factor)IBA
04/2020 - 08/2009
4AnthracyclinesIBA
01/2018 - 05/2011
4Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
08/2017 - 01/2015
4Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2016 - 01/2009
4Methotrexate (Mexate)FDA LinkGeneric
12/2015 - 11/2003
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
05/2015 - 12/2009
4fludarabineIBA
06/2008 - 10/2002
3Immunoconjugates (Immunoconjugate)IBA
01/2022 - 01/2021
3entinostat (MS 275)IBA
01/2019 - 07/2014
3Transforming Growth Factors (Transforming Growth Factor)IBA
12/2017 - 11/2010
3Cyclin D1IBA
12/2016 - 05/2010
3Histone Deacetylases (Histone Deacetylase)IBA
05/2016 - 11/2012
3RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
01/2016 - 01/2014
3PhosphoproteinsIBA
01/2015 - 12/2010
3Tacrolimus (Prograf)FDA LinkGeneric
06/2008 - 11/2003
3Melphalan (Alkeran)FDA LinkGeneric
02/2008 - 10/2002
2B7-H1 AntigenIBA
10/2021 - 02/2018
2EverolimusFDA Link
06/2021 - 01/2019
2AntigensIBA
01/2021 - 02/2007
2GemcitabineFDA Link
01/2021 - 01/2011
2Cisplatin (Platino)FDA LinkGeneric
09/2020 - 01/2020
2Protein Isoforms (Isoforms)IBA
01/2020 - 07/2014
2TamoxifenFDA LinkGeneric
01/2020 - 01/2013
2CytokinesIBA
08/2019 - 12/2017
2AgarIBA
06/2019 - 03/2010
2CholesterolIBA
01/2019 - 04/2015
2TOR Serine-Threonine KinasesIBA
01/2019 - 02/2010
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2019 - 02/2010
2Drug CombinationsIBA
01/2019 - 01/2018
2130-nm albumin-bound paclitaxelIBA
01/2018 - 04/2016
2KW-2450IBA
01/2018 - 12/2015
2N- (2,3- dihydroxypropyl)- 1- ((2- fluoro- 4- iodophenyl)amino)isonicotinamideIBA
08/2017 - 01/2015
2Interleukin-6 (Interleukin 6)IBA
12/2016 - 01/2014
2Bevacizumab (Avastin)FDA Link
04/2016 - 06/2011
2Indicators and Reagents (Reagents)IBA
01/2016 - 07/2014
2Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
12/2015 - 07/2014
2AZD 6244IBA
12/2015 - 02/2012
2Simvastatin (Zocor)FDA LinkGeneric
12/2015 - 07/2014
2PlatinumIBA
12/2015 - 01/2007
2Telomerase (Telomerase Reverse Transcriptase)IBA
01/2015 - 08/2009
2Liposomes (Liposome)IBA
01/2015 - 11/2002

Therapy/Procedure

85Therapeutics
01/2022 - 01/2004
48Drug Therapy (Chemotherapy)
06/2022 - 05/2003
25Neoadjuvant Therapy
01/2022 - 11/2004
13Hematopoietic Stem Cell Transplantation
01/2013 - 05/2003
11Radiotherapy
12/2020 - 02/2008
5Mastectomy (Mammectomy)
08/2021 - 01/2014
4Transplantation
01/2013 - 06/2004
4Stem Cell Transplantation
06/2008 - 11/2003
4Homologous Transplantation
02/2005 - 10/2002
3Immunotherapy
01/2022 - 09/2003
3Adjuvant Chemotherapy
07/2019 - 12/2015
2Modified Radical Mastectomy (Mastectomy, Modified)
08/2021 - 11/2020
2Segmental Mastectomy (Lumpectomy)
10/2017 - 02/2015
2Precision Medicine
11/2016 - 01/2011
2Aftercare (After-Treatment)
12/2015 - 02/2008